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Episode 56, 17 MIN 26 SEC , MP3 FORMAT

Farewell To Dialysis?

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"If an organ undergoes trauma it often fibroses to try to protect the organ or maintain its integrity, but it’s when this aberrant scarring occurs that it excessively causes the deletion of cells or the loss of cell function. " - Assoc Prof Darren Kelly

Darren Kelly

Darren Kelly is Associate Professor at the University of Melbourne, is the Director of Biomedical Research in the Department of Medicine at St Vincent’s Hospital, Melbourne.  He is recognised expert in progressing pre-clinical novel interventions and in developing experimental models of renal and cardiac disease. Darren has published more than 100 manuscripts, with most in high quality journal such as PNAS, Diabetes and American Journal of Pathology.  In particular, many of these manuscripts have led to translational research that has had a direct impact on human disease.  Assoc Prof Kelly has previously received major grants and fellowships from the NH&MRC and Juvenile Diabetes Research Foundation (JDRF) International. Assoc Prof Kelly is also CEO of Fibrotech Therapeutics, a member of the Australian Inst of Company Directors, and a Fellow of the American Society of Nephrology.

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USEFUL LINKS

Publications

  • Ngo DT, Stafford I, Kelly DJ, Sverdlov AL, Wuttke RD, Weedon H, Nightingale AK, Rosenkranz AC, Smith MD, Chirkov YY, Kennedy JA, Horowitz JD.  (2008). Vitamin D(2) supplementation induces the development of aortic stenosis in rabbits: interactions with endothelial function and thioredoxin-interacting protein. Eur J Pharmacol. 590(1-3):290-6
  • Mather, A., Chen, X. M., McGinn, S., Field, M. J., Sumual, S., Mangiafico, S., Zhang, Y., Kelly, D. J., Pollock, C. A. (2008). High glucose induced endothelial cell growth inhibition is associated with an increase in TGFbeta(1) secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway. Int J Biochem Cell Biol.
  • Holian, J.,Qi, W., Kelly, D.J., Zhang, Y., Mreich, E., Pollock, C.A. and Chen, X.M. (2008) The Role of Kruppel-like factor 6 in Transforming Growth Factor-Beta-1-induced Epithelial-Mesenchymal Transition of Proximal Tubule Cells. Am J Physiol Renal Physiol. 
Department of Medicine

CREDITS

Host: Dr Shane Huntington
Producers: Kelvin Param, Eric Van Bemmel and Dr Shane Huntington
Audio Engineer: Craig McArthur
Theme Music performed by Sergio Ercole. Mr Ercole is represented by the Musicians' Agency, Faculty of Music
Voiceover: Paul Richiardi

Series Creators: Eric van Bemmel and Kelvin Param
© The University of Melbourne, 2009. All Rights Reserved.
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